Actively cooled capacitor-feedback headstage reduces thermal noise for signal-to-noise ratios close to the theoretical limits of physics
Integrating headstage mode for measuring sub-picoamp currents to enable high-fidelity single-channel recordings from cell membranes and artificial bilayers
Resistive headstage mode for larger currents and noise levels in whole-cell recordings
Slim headstage design for easier access to the preparation on a crowded microscope stage
Series resistance compensation: Prediction helps achieve the desired command level faster by transiently supercharging the membrane potential
Series resistance compensation: Correction improves the bandwidth of the recording by eliminating the error introduced by the voltage drop across the series resistance
Dual-speed current clamp optimizes speed and stability through better matching of the clamp algorithm to experimental parameters
Integrated seal test in voltage- and current-clamp mode for easy monitoring of membrane and cell health parameters
Dual command potentials add flexibility by processing input signals from two different sources
Selectable holding command input with two internal range settings and an external input enable convenient control of the output waveform
Pipette capacitance compensation neutralizes the contribution of the glass pipette and the pipette holder to the capacitance of the circuitry
Cell capacitance compensation corrects for the capacitance of the cell membrane in whole-cell recordings
Selectable output gain with 10 settings to scale the output signal to the desired level
Leak subtraction for correction of leak currents without software-based algorithms
Sophisticated 4-pole Bessel low-pass filter acts as anti-aliasing filter and can be used to pre-condition the output signal
Configurable panel meter displays user-selectable parameters in real time for quick monitoring of the experiment
Zap facilitates patch rupturing by applying a voltage pulse for a user-defined duration
Two included pipette holders of different barrel lengths accept glass pipettes in most standard dimensions
User guide written by scientific consultants, with the assistance of Axon Instruments staff, for straightforward start-up and as an in-depth reference

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