Support of up to four headstages makes the Multiclamp 700B System four amplifiers in one.
Software control of all amplifier settings for automated optimization features, reduction of manipulation steps, and convenient, reliable telegraphing.
Quick Select Feature recalls up to three saved amplifier configurations for fast, reproducible application switching.
Optional SoftPanel allows amplifier control using knobs and buttons for a more conventional feel to amplifier control.
Integrated seal test in voltage- and current-clamp mode for easy monitoring of membrane and cell health parameters.
Dual Command Potentials add flexibility by processing input signals from two different sources.
Selectable command sensitivity for flexible control of the output waveform.
Pipette offset compensation with auto-mode quickly removes signal offsets.
Automatic pipette capacitance compensation requires only the push of a button to neutralize the contribution of the glass pipette and the pipette holder to the capacitance of the circuitry.
Series resistance compensation: Prediction helps achieve the desired command level faster by transiently supercharging the membrane potential.
Series resistance compensation: Correction improves the bandwidth of the recording by eliminating the error introduced by the voltage drop across the series resistance.
Automatic cell capacitance compensation corrects for the capacitance of the cell membrane in whole-cell recordings with a single mouse click.
Automatic mode switching enables you to control the transition between voltage and current clamp by an external trigger or depending on the recorded signal.
Automatic oscillation detection prevents damage to a cell when electrical feedback occurs.
Leak subtraction for automatic correction of leak currents with a smart, software-based algorithm.
Selectable output gain with 11 settings to scale the output signal to the desired level.
Audio monitor for acoustic tracking of the signal while you are busy looking down a microscope.
Fine-tunable 4-pole bessel and butterworth low-pass filters act as anti-aliasing filters and can be used to pre-condition the output signal.

Applications:

Basic Ion Channel Research: Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell. Learn more.
Cell Pathway Analysis: Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc. Learn more.
Disease Research: Ion channels play a role in many diseases, including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease. Learn more.
Safety Assessment: A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow. Learn more.

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