The IPL-1 is engineered for the most demanding applications. As a result the basic system can easily be upgraded to add capability modules for virtually any ex-vivo pulmonary assay. Due to the fragile nature of the mouse lung, its suspension from the tracheal and vascular cannulae is difficult to accomplish without the rapid occurance of edema. In collaboration with experts in pulmonary physiology, an alternative design was implemented which allows for ventilation and perfusion with the lungs remaining in situ at a slight incline. This novel approach simplifies cannulation of the pulmonary artery and left atrium of the heart and dramatically reduces edema formation. MEASURED SIGNALS & PARAMETERS ON AN IPL-1 BASIC SYSTEM:
The Following Signals are Recorded as Raw Data: Pulmonary Artery (Perfusion) Pressure Perfusion Flow Intrapleural (artificial thorax) Pressure or Tracheal Pressure Respiratory Flow The Following Parameters can be calculated from the Raw Data: Tidal Volume, Minute Volume Respiratory Volume Peak Inspiratory & Expiratory Airflow Vascular Resistance Respiration Rate Inspiratory Time & Expiratory Time End Inspiratory & Expiratory Pressure Dynamic Airway Resistance & Compliance * Calculations are automatic when HSE PULMODYN software is used. FEATURES & BENEFITS Exclusive artificial thorax chamber for isolated lung with integrated changeover system for switch between simple positive-pressure ventilation and physiological negative (subatmospheric pressure ventilation) Integrated surgery table to reduce damage during preparation Unique built-in pneumotachometer and air humidifier with small dead volume Drug injection pathway built directly into pulmonary perfusate stream Low flow resistance and dead space volume minimize perfusion artifacts
Proprietary cannulae are matched to mouse vessel and feature tip occlusion protectors and Mini Ball system which allow cannulae to be fixed, further reducing the incidence of vascular occlusion
For a working unit, the core system requires the addition of a selection of one of the options VCMP, VCMR or PPV-1
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