Product Information

America NEO Company Intelligent Automatic Micromanipulator

Product Name: America NEO Company Intelligent Automatic Micromanipulator
Product Type: PatchMAX 100A
Exhibitors: other brand
Product Documentation: No Related Documents


There United States NEO company provides another set of solutions, that is, the use of automatic manipulator and the traditional patch clamp amplifier, analysis software to build a new patch clamp experimental system.

America NEO Company Intelligent Automatic Micromanipulator  Detailed description
   The system uses a smart manipulator that can automatically detect cells to automate high-impedance sealing with cells, eliminating the need for manual sealing of cells under the microscope, making complex manipulations in conventional patch clamp experiments simple. Efficient! At the same time, the traditional glass electrode high-impedance sealing technology is adopted, and the advantages of low cost of the conventional patch clamp are retained. Multiple patch clamp experiments can be performed simultaneously using multiple smart manipulators.
    The ezPatch, ChannelMAX 100A, and PatchMAX 100A product families make patch clamp and two-electrode voltage clamp (TEVC) experiments easier, more efficient, more cost-effective, more repeatable, and more space-efficient.
1. PatchMAX 100A
Apply to:
    The PatchMAX 100A is a semi-automatic patch clamp system that combines the ChannelMAX 100A, two-electrode voltage clamp, and patch clamp techniques into one unit. Whole cell and single channel recordings can be used to culture cells and oocytes. It occupies only 8" x 8" of the experimental area and is the smallest multi-functional patch clamp system available. The automated patch clamp system replaces the microscope and operator in conventional systems. Through an automated operator, a manual XY mobile station, a data acquisition control system, and a perfusion chamber, the system automatically directs the electrodes to form seals on adherent cells on oocytes, suspension cells, and coverslips.

Main Feature:
    Automated cell membrane detection
    The specially designed perfusion trough ensures that when oocytes or other cells are instilled, the cells can always reach a known location. If the electrode tip is precisely coaxial, the tip of the electrode can reach this position with an accuracy of 0.05 mm. The computer can control the movement of the electrode and stop when the electrode contacts the cell membrane.
    High sealing success rate
    The electrode positioning system provides a large range of speeds and criteria for judging the proximity of cells, allowing researchers to make fine adjustments to create a reliable seal. The computer-controlled system eliminates human error and therefore can achieve a very high sealing success rate. The use of PatchMAX 100A can exceed 90%.
    Save and re-use sealing parameters
    Pathways and sealing parameters close to the cell can be saved and used again. Once you have found a good set of parameters, you can save them for later use or other researchers to use. When a new laboratory technician joins the experiment, he can learn the patch clamp technique using these saved parameters.
    Low noise recording
    During recording, the system is low-noise. After the recording was started, the power of the stepping motor was turned off and the position of the electrode was fixed, thus eliminating the noise from the motor.
    Low drift
    Two modular wedge-shaped linear movement axes can be set and locked in position. They are not vulnerable to shocks and vibrations. Even without power, the motor movement axis can be maintained in its own tiny position (50 nm accuracy). Throughout the night. The patch clamp electrode is fixed by a support arm, and even when the electrode holder is touched, the movement of the electrode tip is not obvious. There are few moving parts in the entire system, so the drift is very small.
     Easy experiment and vibration-free
     With PatchMAX 100A, patch clamp experiments have become easier. Because the operator is controlled by the computer, the experimenter does not need to touch the operator during the experiment. The computer will control the formation of the seal, and it can always be easily and accurately repeated.
    Use standard glass electrode
    Unlike traditional high-throughput systems, this system does not require the use of expensive "sealed chips" but uses standard glass electrodes, which greatly reduces the cost of the experiment.
    Manual control mode
    In addition to the computer-controlled automatic mode, you can also select the manual mode to control the operator by clicking the mouse.
    Quick change solution
    Two specially designed perfusion slots allow quick solution changes.
2. ChannelMAX 100A Mini
Apply to:
    The patent is designed based on the PatchMAX 100A, but uses two computer-controlled operators that can simultaneously perform two patch clamp recordings or a two-electrode voltage clamp recording. This can effectively improve efficiency, reduce experimental costs and save space. The system is controlled by a computer and experimentation becomes very easy.
Main Feature:
    Run two patch clamp experiments simultaneously
    The ChannelMAX 100A Mini uses two computer-controlled operators that can run two patch clamp experiments at the same time, providing researchers with a better basis for decision-making. Single-channel activities are random events. It is difficult to understand what is happening by observing the opening and closing of channels, especially when studying a new channel. For example, if there are two channels on the same diaphragm, it is difficult to identify the path with two open steps. Using two diaphragms treated with the same conditions can provide more information and make the right decisions for the data obtained on some rare seals.
    High-quality patch clamp
    Like the PatchMAX 100A, the ChannelMAX 100A features low noise and low drift. The computer-controlled system eliminates human error and the success rate of high-resistance sealing exceeds 90%.
    Run two independent patch clamp experiments
    Two independent patch clamp experiments can be easily performed by changing the configuration. As shown in the right figure, it is easy to use two perfusion slots on the same table.
    Automated two-electrode voltage clamp
    For two-electrode voltage clamps, the puncture cells are controlled by the computer and therefore do not require a microscope. When the electrode enters the oocyte, the membrane potential changes and the movement of the electrode stops. The user can define the threshold of the membrane potential and the delay time until the electrode stops after the electrode enters the oocyte.
    Save space
    The system is suitable for two-electrode voltage clamps and patch clamps. Only one data acquisition system is needed. All data is on one computer for easy comparison of data.
    Easy switching between patch clamp and dual electrode voltage clamp
    The system design takes full account of the switching between the patch clamp and the two-electrode voltage clamp. With adjustable components, the system can be used with different amplifiers, and glass electrodes of different lengths can be used.
    Used with traditional two-electrode voltage clamp
    The ChannelMAX 100A Mini can be used simultaneously with a conventional two-electrode voltage clamp while running two two-electrode voltage clamp experiments.
    High efficiency, low strength

    The system is automated, and experiments can be run in parallel to increase efficiency, greatly reducing the high-intensity operation of conventional and dual-electrode voltage clamps.

3. ChannelMAX 100A Twin

Apply to:
    The system is similar to the ChannelMAX 100A Mini, but two dual-electrode voltage clamp experiments or four patch clamp experiments can be performed simultaneously.
Main Feature:
    Two dual-electrode voltage clamp experiments can be run simultaneously
    By using two additional micromanipulators, the system can simultaneously perform two two-electrode voltage clamp experiments. At prices acceptable to the institute, the system significantly increased the amount of data produced. By parallel expansion, the flux of the double-electrode voltage clamp experiment can be further improved.
    Can run four patch clamping experiments simultaneously
    Each operator can perform a patch clamp experiment. The ChannelMAX 100A Twin provides four operators, so four patch clamp experiments can be run simultaneously, which significantly increases the data for the patch clamp experiment.
    High quality sealing
    Because the computer-controlled operator guides the electrode to contact the cell membrane, it is more precise and coordinated than the manual control of the micromanipulator, and the success rate of seal formation is more than 90%. The system has the same high quality, low noise, and low drift.
    Maximum flexibility
    The user can control each robot by software, which is similar to manually controlling the operator. Each manipulator can be moved and repositioned, and manual XY axes allow precise adjustment of position. The system can use different lengths of glass electrodes.
    Save lab space
    With only 12 in x 12 in, the ChannelMAX 100A Twin combines multiple two-electrode voltage clamps with multiple patch clamp systems, significantly reducing the need for laboratory space.
    Low intensity
    The ChannelMAX 100A Twin system reduces experimental intensity through automation.
    Publish data faster
    This configuration doubles the efficiency of the ChannelMAX 100A Mini and therefore provides more data. If you use a traditional two-electrode voltage clamp system to do 50 oocytes per week, you can use this system to obtain data for 100 oocytes per week.
Main components:
• PatchMAX 100A: A micromanipulator (including a linear motor shaft and a manual XY shaft), a perfusion slot and a platform.
• ChannelMAX 100A Mini: Dual micromanipulators (each micromanipulator hand contains a motor linear axis and a manual XY axis), a perfusion slot and platform.
• ChannelMAX 100A Twin: Four micromanipulators (each micromanipulator hand contains a motor linear axis and a manual XY axis), two perfusion slots and platforms.

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