Product Information

Orbit 16

Product Name: Orbit 16
Product Type: Orbit 16
Exhibitors: Aurora
Product Documentation: No Related Documents

Brief

Orbit 16 instantly completes the lipid bilayer experiment - add protein.


Orbit 16  Detailed description
    Lipid bilayer experiments usually take a long time to wait for the formation of lipid bilayers, the addition of proteins, and the eventual recording of ion channel activity. Orbit16 can get rid of the pain of the lipid bilayer experiment and get a lot of data quickly. This all stems from the rapid formation and parallel recording of 16 lipid bilayers.

Orbit 16 has:
- Automatically complete 16 lipid double layers with a single button
- Low noise ultra wideband recording
- Compatible with many types of chips, allowing great flexibility in experimentation
- Simultaneous recording of 16 tracks, continuous generation of large amounts of experimental data
    Most of the commercially available amplifiers on the Orbit 16 market are compatible with Orbit16, including Tecella's amplifier Triton. For single-channel amplifiers, such as the EPC-10 or Axonpatch, Orbit has a built-in multiplexer that automatically converts recording locations to achieve multi-site recording.

Standard experiment unit
A complete Orbit16 platform includes a master recording station, an amplifier plus multiplexer, and two recording modules (fit for Ionera's MECA chip and Nanion's GUV recording chip, respectively).
MECA-chip MECA - loncera'
The MECA recording board was fabricated on a high-inert polymer backplane with a 4x4 array of circulating microcavities. Each cavity contains a set of Ag/AgCl electrodes. The lipid bilayer is formed automatically by precise remote control and the top fills the cavity with liquid.
[1] Ionera (www.ionera.de), a spin-off from the University of Freiburg, Germany, will be the OEM for the MECA (microelectrode cavity array) chip.



GUV-chipGUV chip
With Port-a-Patch, we can know that the use of microporous glass chips allows low-noise recording of ion channels that are recombined in lipid bilayers without electrolyte. The lipid bilayer here is formed by the disruption of a large single compartment vesicle (GUV) and covering the microporous glass chip. The GUV is absorbed by a gentle negative pressure and can simultaneously form 16 lipid bilayers without electrolyte. Calibration work is in progress!


Orbit mini. Insert and apply
Orbit mini supports:
Simultaneous recording of 4 lipid bilayers
Low noise, high bandwidth recording
Temperature Control - Effective Cooling and Heating
Economic One-time MECA Chip Lab Consumables


    The Orbit mini includes a built-in, miniaturized four-channel amplifier that allows low-noise recording with high bandwidth without additional equipment—you can experiment in real-time even on a train! Thanks to the Orbit mini's unique design, the measuring cell temperature can be controlled effectively without generating additional noise.
    A complete Orbitmini platform consists of a main recording unit (element) containing a built-in four-channel amplifier and a computer-controlled environmental control unit that effectively cools and heats the recording trough. Lonera's 16-channel MECA disposable chip was used for manual smearing of lipid bilayers and parallel recording of 4 lipid bilayers.

MECA recording substrate (lonera)
    The MECA recording substrate contains a 2x2 annular microcavity array embedded in a highly inert polymer. Each microcavity contains an independently integrated Ag/AgCl microelectrode. A functional lipid bilayer with high success rate is formed by smearing. MECA chips have been successfully applied to many different ion channel studies, including KcsA, gramicidin, α-hemolysin, Kv1.3, and sodium channels.
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